![]() ![]() Through a reporter assay for per1 transcription, we demonstrate that blue light at 410 nm decreases per1 transcription in keratinocytes, showing that epidermal skin cells can sense light directly and control their own clock gene expression. Here, we asked the question if blue light could be a direct entrainment signal to skin cells and also disrupt their circadian rhythm at night. ![]() The strongest clue for determining cellular functions timing is through sensing light or absence of light (darkness). ![]() Circadian rhythm provides the precise timing mechanism for engaging those different pathways necessary to keep a healthy skin through clock genes that are present in all skin cells. Over a 24-h natural cycle, during the day, the skin is focused on protection while at night, the skin is focused on repairing damage that occurred during daytime and getting ready for the next morning. On a daily basis, the skin is exposed to many environmental stressors and insults. ![]()
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